Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Stress and Childhood Asthma Risk: Overlapping Evidence from Animal Studies and Epidemiologic Research. | ORIGINAL ARTICLE Stress and Childhood Asthma Risk Overlapping Evidence from Animal Studies and Epidemiologic Research Rosalind J. Wright MD MPH Rapidly expanding evidence increasingly strengthens the evidence linking psychological factors to asthma and allergy expression. Parallel studies in animals and humans demonstrating the influence of prenatal maternal stress and early caregiving experiences on the disrupted regulation of defensive biological systems eg sympathetic and adrenomedullary SAM system and the hypothalamic-pituitary-adrenocortical HPA axis provide strong proof of concept for this line of research. The consequent altered neuroimmune responses may influence the expression of immune-mediated disorders such as asthma as well as enhance an individual s susceptibility to other environmental factors that may also contribute to asthma risk. Key words asthma childhood interactions prenatal stress Introduction Efforts to understand the role of psychological stress in asthma expression and atopy are currently undergoing rapid expansion in the context of our increased understanding of both the neurobiology of stress and asthma pathophysiology 1 as well as trying to determine why asthma remains a leading cause of health disparities largely unexplained by known physical environmental 3 Notably consensus statements by both the National Academy of Science and the National Institute of Environmental Health Sciences4 support the position that examining disparities in environmental health requires attention to both environmental hazards and social Although a number of theoretical models explaining health disparities have been proposed a psychosocial stress model may offer the greatest 6 7 With an estimated half of all cases diagnosed by age 3 years and two-thirds diagnosed by age 5 years asthma is a developmental This developmental framework presupposes that adverse early-life experiences including Rosalind J. Wright .
