Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Importance of basophil activation testing in insect venom allergy. | Allergy Asthma Clinical Immunology BioMed Central Open Access Review Importance of basophil activation testing in insect venom allergy Mitja Kosnik and Peter Korosec Address University Clinic of Respiratory and Allergic Diseases Golnik Slovenia Email Mitja Kosnik - Peter Korosec - Corresponding author Published I December 2009 Received 5 November 2009 Allergy Asthma Clinical Immunology 2009 5 11 doi 1710-1492-5-11 Accepted 1 December 2009 This article is available from http content 5 1 1 1 2009 Kosnik and Korosec licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Venom immunotherapy VIT is the only effective treatment for prevention of serious allergic reactions to bee and wasp stings in sensitized individuals. However there are still many questions and controversies regarding immunotherapy like selection of the appropriate allergen safety and long term efficacy. Methods Literature review was performed to address the role of basophil activation test BAT in diagnosis of venom allergy. Results In patients with positive skin tests or specific IgE to both honeybee and wasp venom IgE inhibition test can identify sensitizing allergen only in around 15 and basophil activation test increases the identification rate to around one third of double positive patients. BAT is also diagnostic in majority of patients with systemic reactions after insect stings and no detectable IgE. High basophil sensitivity to allergen is associated with a risk of side effects during VIT. Persistence of high basophil sensitivity also predicts a treatment failure of VIT. Conclusion BAT is a useful tool for better selection of allergen for .
