Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Panallergens and their impact on the allergic patient. | Hauser et al. Allergy Asthma Clinical Immunology 2010 6 1 http content 6 1 1 ALLERGY ASTHMA CLINICAL IMMUNOLOGY REVIEW Open Access Panallergens and their impact on the allergic patient Michael Hauser Anargyros Roulias Fatima Ferreira Matthias Egger Abstract The panallergen concept encompasses families of related proteins which are involved in general vital processes and thus widely distributed throughout nature. Plant panallergens share highly conserved sequence regions structure and function. They are responsible for many IgE cross-reactions even between unrelated pollen and plant food allergen sources. Although usually considered as minor allergens sensitization to panallergens might be problematic as it bears the risk of developing multiple sensitizations. Clinical manifestations seem to be tightly connected with geographical and exposure factors. Future population- and disease-based screenings should provide new insights on panallergens and their contribution to disease manifestations. Such information requires moleculebased diagnostics and will be valuable for developing patient-tailored prophylactic and therapeutic approaches. In this article we focus on profilins non-specific lipid transfer proteins polcalcins and Bet v 1-related proteins and discuss possible consequences of panallergen sensitization for the allergic patient. Based on their pattern of IgE cross-reactivity which is reflected by their distribution in the plant kingdom we propose a novel classification of panallergens into ubiquitously spread real panallergens . profilins and widespread eurallergens . polcal-cins . Stenallergens display more limited distribution and cross-reactivity patterns and monallergens are restricted to a single allergen source. Introduction So far from more than 200 000 known plant species about 50 are registered in the official allergen list of the International Union of Immunological Societies IUIS Allergen Nomenclature Subcommittee http .
