Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Hereditary angioedema in women. | Bouillet Allergy Asthma Clinical Immunology 2010 6 17 http content 6 1 17 ALLERGY ASTHMA CLINICAL IMMUNOLOGY REVIEW Open Access Hereditary angioedema in women Laurence Bouillet Abstract Women with hereditary angioedema HAE are more likely to be symptomatic that men. Hormonal factors puberty contraception pregnancy . play a significant role in the precipitation or worsening of the condition in women. So combined contraceptive pills are not indicated and progestogen pill must be preferred. During pregnancy attack rate can increase 38-48 of women . C1Inhibitor concentrate and tranexamic acid can be used during pregnancy. Attenuated androgens for long term prophylaxis are effective but side effects appear more often in female patients. These side effects are dose dependant and can be attenuated by titrating the dose down the lowest effective level. Review Hereditary angioedema HAE is inherited in an autosomal dominant manner consequently both women and men can be affected. However published series of hereditary angioedema report a clear female predominance 60 1 2 . This might be explained by the fact that women are more likely to be symptomatic than men. In HAE associated with C1 Inh deficiency Professor Bork has shown that women have more clinical episodes than men p 2 . Hormonal factors play a significant role in the precipitation or worsening of the condition in women. There appear to be variation in overall frequency of angioe-dema symptoms according to the different female life stages of childhood puberty menses pregnancies and menopause. Reports have noted a close relationship between female hormones and angioedema a mother and her daughter whose HAE-related symptoms appeared to be sex hormone dependent 3 . Their first attack happened around puberty angioedema worsened premenstrual and when they took combined oral contraceptives. The case of a woman 4 with HAE and Turner s syndrome is also very interesting starting physiological oestrogen
