Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: On demand treatment and home therapy of hereditary angioedema in Germany - the Frankfurt experience. | Aygoren-Pursun et al. Allergy Asthma Clinical Immunology 2010 6 21 http content 6 1 21 ALLERGY ASTHMA CLINICAL IMMUNOLOGY RESEARCH Open Access On demand treatment and home therapy of hereditary angioedema in Germany - the Frankfurt experience Emel Aygoren-Pursun Inmaculada Martinez-Saguer Eva Rusicke Thomas Klingebiel Wolfhart Kreuz Abstract Background Manifestation of acute edema in hereditary angioedema HAE is characterized by interindividual and intraindividual variability in symptom expression over time. Flexible therapy options are needed. Methods We describe and report on the outcomes of the highly individualized approach to HAE therapy practiced at our HAE center in Frankfurt Germany . Results The HAE center at the Frankfurt University Hospital currently treats 450 adults with HAE or AAE and 107 pediatric HAE patients with highly individualized therapeutic approaches. of the adult patients treat HAE attacks by on-demand therapy with pasteurized pd C1-INH concentrate use additional prophylaxis with attenuated androgens 1 of the total patient population in Frankfurt has been treated with Icatibant up to now. In addition adult and selected pediatric patients with a high frequency of severe attacks are instructed to apply individual replacement therapy IRT with pasteurized pd C1-INH concentrate. Improvement on Quality of Life items was shown for these patients compared to previous long-term danazol prophylaxis. Home treatment of HAE patients was developed in the Frankfurt HAE center in line with experiences in hemophilia therapy and has so far been implemented over a period of 28 years. At present 248 55 of the adult patients and 26 24 of the pediatric patients are practicing home treatment either as on demand or IRT treatment. Conclusions In conclusion the individualized home therapies provided by our HAE center aim to limit the disruption to normal daily activities that occurs for many HAE patients. Furthermore we seek to optimize
