Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Quantitative expression of osteopontin in nasal mucosa of patients with allergic rhinitis: effects of pollen exposure and nasal glucocorticoid treatment. | O Neil et al. Allergy Asthma Clinical Immunology 2010 6 28 http content 6 1 28 ALLERGY ASTHMA CLINICAL IMMUNOLOGY RESEARCH Open Access Quantitative expression of osteopontin in nasal mucosa of patients with allergic rhinitis effects of pollen exposure and nasal glucocorticoid treatment 1 1 2 1 11 Serena E O Neil Carina Malmhall Konstantinos Samitas Teet Pullerits Apostolos Bossios Jan Lotvall Abstract Background Osteopontin OPN is a multifunctional cytokine that has been primarily investigated in Th1 diseases. Recently it has also been implicated in Th2-mediated allergic diseases such as asthma. The expression of OPN in allergic rhinitis AR is currently unknown as is the effect of intranasal glucocorticosteroids GCs on that expression. Methods Subjects with AR were randomised to receive treatment with fluticasone propionate FP n 12 or a placebo n 16 over the grass pollen season and nasal biopsies were taken prior to and during the season. OPN expression in the nasal mucosa was examined with immunohistochemistry. Healthy non-AR controls n 5 were used as a comparator. Results OPN expression was detected in epithelial cells subepithelial infiltrating inflammatory cells and cells lining the vessels and glands of all subjects. Comparison of the pre- and peak-pollen season biopsy sections in placebo treated patients revealed no increase in OPN expression during the grass pollen season vs . Treatment with a local glucocorticosteroid did not alter the expression of OPN during pollen exposure vs . Conclusion OPN has been increasingly associated with the pathogenesis of various Th2-mediated diseases. However our finding that the OPN expression in the nasal mucosa of AR patients is not significantly affected by allergen exposure and is comparable to that of the healthy controls suggests that intracellular OPN is not directly involved in the pathogenesis of allergic rhinitis. Background The inflammatory process in allergic rhinitis AR .
