Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The identification of eosinophilic gastroenteritis in prednisone-dependent eosinophilic bronchitis and asthma. | Nair et al. Allergy Asthma Clinical Immunology 2011 7 4 http content 7 1 4 ALLERGY ASTHMA CLINICAL IMMUNOLOGY CASE REPORT Open Access The identification of eosinophilic gastroenteritis in prednisone-dependent eosinophilic bronchitis and asthma 1 2 2 1 2 2 Parameswaran Nair Sergei I Ochkur Cheryl Protheroe Elizabeth Simms Nancy A Lee James J Lee Abstract This case reports the unique association of eosinophilic gastrointestinal disease with eosinophilic bronchitis asthma and chronic rhinosinusitis and some features of lymphocytic hypereosinophilic syndrome describes a diagnostic protocol for patients with asthma and persistent eosinophilic bronchitis and suggests that the use of a novel EPX-mAb provides a reliable method to identify eosinophilic inflammation. Introduction Eosinophilic gastrointestinal disease EGID is characterized by identification of abnormal eosinophilic infiltration on morphologic evaluation of gastrointestinal tissues obtained by biopsy or resection from patients with gastrointestinal complaints 1 . EGIDs are classified according to the site involved . esophageal gastric small intestinal colonic or multiple . Esophagus is increasingly being recognized as a site of involvement with eosinophils accumulating in the mucosal muscular serosal diffuse or transmural areas 2 . The diagnosis for eosinophilic esophagitis and other EGIDs is established after ruling out other causes of an eosinophilic disease particularly atopy parasitic infestations vasculitis and hypereosinophilic syndrome HES 3 . We report the association of eosinophilic gastroenteritis and eosinophilic bronchitis in a young patient with prednisone-dependent asthma and some features of lymphocytic hypereosinophilic syndrome and the sensitivity of a novel monoclonal antibody directed against eosinophil peroxidase EPX-mAb 4 as an unambiguous means with which to detect both infiltrating tissue eosinophils and eosinophil degranulation in gastrointestinal tract biopsies.
