Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: A case study evaluating the use of clozapine in depression with psychotic features. | BioMed Central Annals of General Psychiatry Case study Open Access A case study evaluating the use of clozapine in depression with psychotic features Premkumar Jeyapaul 1 and Ray Vieweg2 Address 1Wimborne and Purbeck community mental health team Oakley bungalow 15 Oakley Lane Canford Magna Wimborne Dorset BH21 1SF UK and 2The Beeches St James Hospital Portsmouth Hampshire PO4 8LD UK Email Premkumar Jeyapaul - RayVieweg- Corresponding author Published 29 November 2006 Received II September 2006 _ _ _ __ _ Accepted 29 November 2006 Annals of General Psychiatry 2006 5 20 doi 1744-859X-5- p 20 This article is available from http content 5 1 20 2006 Jeyapaul and Vieweg licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The purpose of this case study was to use an evidence based medicine approach to work through an unusual way of treating a common problem. We looked at an example of an in-patient with severe refractory psychotic depression who had been resistant to treatment with a combination of antidepressant antipsychotics mood stabiliser and concomitant ECT therapy. We then undertook a literature search for the use of clozapine in a patient with severe refractory depression. Although the resulting evidence was low level and thin we felt on balance that a trial of clozapine was justified. We used a BPRS inventory to monitor her mood prior to commencing clozapine. Her mood and functional abilities were monitored as her clozapine was titrated upwards. Our patient showed a significant improvement in mood and functional abilities and a reduction in her BPRS score during this period. Her symptoms
