Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Depression, osteoporosis, serotonin and cell membrane viscosity between biology and philosophical anthropology. | Cocchi et al. Annals of General Psychiatry 2011 10 9 http content 10 1 9 REVIEW ANNALS OF GENERAL PSYCHIATRY Open Access Depression osteoporosis serotonin and cell membrane viscosity between biology and philosophical anthropology Massimo Cocchi1 2 Lucio Tonello1 Fabio Gabrielli1 and Massimo Pregnolato1 3 Abstract Due to the relationship between biology and culture we believe that depression understood as a cultural and existential phenomenon has clear markers in molecular biology. We begin from an existential analysis of depression constituting the human condition and then shift to analysis of biological data confirming according to our judgment its original ontological structure. In this way philosophy is involved at the anthropological level in as much as it detects the underlying meanings of depression in the original biological-cultural horizon of human life. Considering the integration of knowledge it is the task of molecular biology to identify the aforementioned markers to which the existential aspects of depression are linked to. In particular recent works show the existence of a link between serotonin and osteoporosis as a result of a modified expression of the low-density lipoprotein receptor-related protein 5 gene. Moreover it is believed that the hereditary or acquired involvement of tryptophan hydroxylase 2 Tph2 or 5-hydroxytryptamine transporter 5-HTT is responsible for the reduced concentration of serotonin in the central nervous system causing depression and affective disorders. This work studies the depression-osteoporosis relationship with the aim of focusing on depressive disorders that concern the quantitative dynamic of platelet membrane viscosity and interactome cytoskeleton modifications in particular Tubulin and Gsa protein as a possible condition of the involvement of the serotonin axis gut brain and platelet not only in depression but also in connection with osteoporosis. Depression and existential .
