Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Complement C3 serum levels in anorexia nervosa: a potential biomarker for the severity of disease? | Flierl et al. Annals of General Psychiatry 2011 10 16 http content 10 1 16 ANNALS OF GENERAL PSYCHIATRY PRIMARY RESEARCH Open Access Complement C3 serum levels in anorexia nervosa a potential biomarker for the severity of disease A A I I A I I 1 I -c I 9 A II I í- 1 94 z I I s FV I I I . I I 1 S I FV I I Í- A A I I 9 9 Michael A Flierl Jennifer L Gaudiani 2 Allison L Sabel Carlin S Long5 Philip F Stahel1 6 and Philip S Mehler2 3 Abstract Background Anorexia nervosa carries the highest mortality rate of any psychiatric disorder. Even the most critically ill anorexic patients may present with normal standard laboratory values underscoring the need for a new sensitive biomarker. The complement cascade a major component of innate immunity represents a driving force in the pathophysiology of multiple inflammatory disorders. The role of complement in anorexia nervosa remains poorly understood. The present study was designed to evaluate the role of complement C3 levels the extent of complement activation and of complement hemolytic activity in serum as potential new biomarkers for the severity of anorexia nervosa. Patients and methods This was a prospective cohort study on 14 patients with severe anorexia nervosa as defined by a body mass index BMI 14 kg m2. Serum samples were obtained in a biweekly manner until hospital discharge. A total of 17 healthy subjects with normal BMI values served as controls. The serum levels of complement C3 C3a C5a sC5b-9 and of the 50 hemolytic complement activity CH50 were quantified and correlated with the BMIs of patients and control subjects. Results Serum C3 levels were significantly lower in patients with anorexia nervosa than in controls median interquartile range IQR vs IQR P . In contrast complement activation fragments and CH50 levels were not significantly different between the two groups. There was a strong correlation between index C3 levels and BMI Spearman .
