Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The role of cyclooxygenase-2 in bone repair. | Available online http content 5 1 5 Commentary COX-2 where are we in 2003 The role of cyclooxygenase-2 in bone repair Thomas A Einhorn Professor and Chairman Department of Orthopedic Surgery Boston University Medical Center Boston Massachusetts USA Corresponding author Thomas A Einhorn Received 13 September 2002 Accepted 26 September 2002 Published 21 October 2002 Arthritis Res Ther 2003 5 5-7 DOI ar607 2003 BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 See related commentaries pages 8 25 and 28 Abstract Prostaglandins are important mediators of bone repair and cyclooxygenases are required for prostaglandin production. Data from animal studies suggest that both non-specific and specific inhibitors of cyclooxygenases impair fracture healing but that this is due to the inhibition of COX-2 and not COX-1. Although these data raise concerns about the use of COX-2-specific inhibitors as antiinflammatory or anti-analgesic drugs in patients undergoing bone repair clinical reports have been inconclusive. Because animal data suggest that the effects of COX-2 inhibitors are both dosedependent and reversible in the absence of scientifically sound clinical evidence it is suggested that physicians consider short-term administration or other drugs in the management of these patients. Keywords bone repair cyclooxygenase-2 fracture healing non-steroidal anti-inflammatory drugs prostaglandins Introduction Bone repair is a complex process involving the participation of several cell types signal transduction pathways and biochemical events 1 . Because it is initiated by a skeletal injury which induces an inflammatory response chemical mediators of inflammation are also involved in this process 2 . Prostaglandins a class of compounds known to mediate inflammation and shown to have effects on bone formation and resorption are essential in bone repair 3 . Prostaglandin synthesis is initiated with the release of arachidonic acid from membrane
