Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Heterogeneity of CD4+ and CD8+ memory T cells in localized and generalized Wegener’s granulomatosis. | Available online http content 5 1 R25 Research article Open Access Heterogeneity of CD4 and CD8 memory T cells in localized and generalized Wegener s granulomatosis Peter Lamprecht1 Anika Erdmann1 Antje Mueller1 Elena Csernok1 Eva Reinhold-Keller1 Konstanze Holl-Ulrich2 Alfred C Feller2 Hilke Bruehl3 and Wolfgang L Gross1 1 Department of Rheumatology University of Luebeck and Rheumaklinik Bad Bramstedt Ratzeburger Allee 160 23538 Luebeck Germany institute of Pathology University of Luebeck and Rheumaklinik Bad Bramstedt Ratzeburger Allee 160 23538 Luebeck Germany 3Medical Policlinic University of Munich Pettenkoferstrasse 8a 80336 Munich Germany These authors contributed equally to the work. Corresponding author Peter Lamprecht e-mail lamprecht@ Received 30 May 2002 Revisions received 27 September 2002 Accepted 8 October 2002 Published 24 October 2002 Arthritis Res Ther 2003 5 R25-R31 DOI ar610 2003 Lamprecht et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any non-commercial purpose provided this notice is preserved along with the article s original URL. Abstract Memory T cells display phenotypic heterogeneity. Surface antigens previously regarded as exclusive markers of naive T cells such as L-selectin CD62L can also be detected on some memory T cells. Moreover a fraction of CD45RO positive for the short human isoform of CD45 memory T cells reverts to the CD45RA positive for the long human isoform of CD45 phenotype. We analyzed patients with biopsy-proven localized Wegener s granulomatosis WG n 5 generalized WG n 16 and age- and sex-matched healthy controls n 13 to further characterize memory T cells in WG. The cellsurface expression of CD45RO CD45RA CD62L CCR3 CCR5 and CXCR3 was determined on blood-derived T cells by four-color flow cytometric analysis. The fractions of .
