Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Decreased effector memory CD45RA+CD62L– CD8+ T cells and increased central memory CD45RA–CD62L+ CD8+ T cells in peripheral blood of rheumatoid arthritis patients. | Available online http content 5 2 R91 Research article Open Access Decreased effector memory CD45RA CD62L- CD8 T cells and increased central memory CD45RA-CD62L CD8 T cells in peripheral blood of rheumatoid arthritis patients Anastacia Maldonado1 Yvonne M Mueller2 Preethi Thomas1 Paul Bojczuk2 Carolyn O Connors1 and Peter D Katsikis2 Department of Medicine Drexel University College of Medicine Drexel University Philadelphia Pennsylvania USA 2Department of Microbiology and Immunology Drexel University College of Medicine Drexel University Philadelphia Pennsylvania USA Corresponding author Peter D Katsikis e-mail katsikis@ Received 13 August 2002 Revisions received 14 October 2002 Accepted 19 November 2002 Published 6 January 2003 Arthritis Res Ther 2003 5 R91-R96 DOI ar619 2003 Maldonado et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any non-commercial purpose provided this notice is preserved along with the article s original URL. Abstract Although a role for CD8 T cells in the pathogenesis of rheumatoid arthritis RA has been suggested the precise nature of their involvement is not fully understood. In the present study we examined the central and effector memory phenotypes of CD4 and CD8 T cells in the peripheral blood of patients with RA and systemic lupus erythematosus. Terminally differentiated effector memory CD45RA CD62L-CD8 T cells were significantly decreased in RA patients whereas the central memory CD45RA-CD62L CD8 T-cell population was increased as compared with levels in healthy control individuals. Naive and preterminally differentiated effector memory CD45RA-CD62L- CD8 T cells did not differ between RA patients and control individuals. The CD45RA-CD62L central memory CD4 T-cell subpopulation was increased in RA patients whereas the naive and effector memory phenotype
