Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Advanced glycation end-product (AGE)-damaged IgG and IgM autoantibodies to IgG-AGE in patients with early synovitis. | Arthritis Research Therapy Vol 5 No 2 Newkirk et al. Research article Open Access Advanced glycation end-product AGE -damaged IgG and IgM autoantibodies to IgG-AGE in patients with early synovitis Marianna M Newkirk1 Raphaela Goldbach-Mansky2 Jennifer Lee2 Joseph Hoxworth2 Angie McCoy2 Cheryl Yarboro2 John Klippel2 Hani S El-Gabalawy2 3 1McGill University Health Centre Montreal Quebec Canada 2National Institutes of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health Bethesda Maryland USA 3Current address University of Manitoba Winnipeg Manitoba Canada The first two authors contributed equally to this work Corresponding author M Newkirk e-mail Received 18 July 2002 Revisions received 5 November 2002 Accepted 21 November 2002 Published 6 January 2003 Arthritis Res Ther 2003 5 R82-R90 DOI ar622 2003 Newkirk et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any non-commercial purpose provided this notice is preserved along with the article s original URL. Abstract Advanced glycation end-product AGE -damaged IgG occurs as a result of hyperglycemia and or oxidative stress. Autoantibodies to IgG-AGE were previously demonstrated in patients with severe longstanding rheumatoid arthritis RA . We investigated whether IgG-AGE and anti-IgG-AGE antibodies were present early in the course of RA and other inflammatory arthropathies. We prospectively followed a cohort of 238 patients with inflammatory arthritis of duration less than 1 year. Patients were evaluated clinically and serologically and radiographs were obtained at initial and 1-year visits. Sera were assayed for IgG-AGE and anti-IgG-AGE antibodies by enzyme-linked immunosorbent assay ELISA . Rheumatoid factor RF was determined by nephelometry and ELISA. Of all patients 29 had RF-positive RA 15 had RF-negative RA 18 had
