Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis. | Arthritis Research Therapy Vol 5 No 2 Bardos et al. Research article Open Access CD4 CD25 immunoregulatory T cells may not be involved in controlling autoimmune arthritis Tamas Bardos1 Matyas Czipri1 Csaba Vermes1 Alison Finnegan2 3 Katalin Mikecz1 3 4 and Jian Zhang1 3 Section of Biochemistry and Molecular Biology Department of Orthopedic Surgery Rush University at Rush-Presbyterian-St. Luke s Medical Center Chicago Illinois USA 2Department Internal Medicine Rush University at Rush-Presbyterian-St. Luke s Medical Center Chicago Illinois USA 3Department Immunology Microbiology Rush University at Rush-Presbyterian-St. Luke s Medical Center Chicago Illinois USA 4Department of Biochemistry Rush University at Rush-Presbyterian-St. Luke s Medical Center Chicago Illinois USA Corresponding author Jian Zhang e-mail jian_zhang@ Received 11 October 2002 Revisions received 25 November 2002 Accepted 17 December 2002 Published 20 January 2003 Arthritis Res Ther 2003 5 R106-R113 DOI ar624 2003 Bardos et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any non-commercial purpose provided this notice is preserved along with the article s original URL. Abstract Accumulating evidence suggests that regulatory T cells play a crucial role in preventing autoimmunity. Recently a naturally occurring CD4 CD25 T-cell subset that is anergic and also suppressive has been shown to suppress autoimmunity in several animal models. We used proteoglycan-induced arthritis PGIA as a study model to investigate the role of the CD4 CD25 regulatory T cells in autoimmune arthritis. There was no significant change in the percentage of CD4 CD25 T cells during the immunization period when proteoglycan- or ovalbumin-immunized BALB c and C57BL 6 mice were Keywords arthritis autoimmunity peripheral tolerance regulatory T cells compared. An adoptive .
