Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The clinical relevance of autoantibodies in scleroderma. | Arthritis Research Therapy Vol 5 No 2 Ho and Reveille Review The clinical relevance of autoantibodies in scleroderma Khanh T Ho and John D Reveille Division of Rheumatology and Clinical Immunogenetics and General Medicine The University of Texas-Houston Health Science Center UTH-HSC Houston Texas USA Corresponding author John D Reveille e-mail Received 14 November 2002 Revisions received 14 January 2003 Accepted 17 January 2003 Published 12 February 2003 Arthritis Res Ther 2003 5 80-93 DOI ar628 2003 BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 Abstract Scleroderma systemic sclerosis is associated with several autoantibodies each of which is useful in the diagnosis of affected patients and in determining their prognosis. Anti-centromere antibodies ACA and anti-Scl-70 antibodies are very useful in distinguishing patients with systemic sclerosis SSc from healthy controls from patients with other connective tissue disease and from unaffected family members. Whereas ACA often predict a limited skin involvement and the absence of pulmonary involvement the presence of anti-Scl-70 antibodies increases the risk for diffuse skin involvement and scleroderma lung disease. Anti-fibrillarin autoantibodies which share significant serologic overlap with anti-U3-ribonucleoprotein antibodies and anti-RNA-polymerase autoantibodies occur less frequently and are also predictive of diffuse skin involvement and systemic disease. Anti-Th To and PM-Scl in contrast are associated with limited skin disease but anti-Th To might be a marker for the development of pulmonary hypertension. Other autoantibodies against extractable nuclear antigens have less specificity for SSc including anti-Ro which is a risk factor for sicca symptoms in patients with SSc and anti-U1-ribonucleoprotein which in high titer is seen in patients with SSc systemic lupus erythematosus polymyositis overlap syndromes. Limited reports of other autoantibodies anti-Ku .
