Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Transcription profiling of rheumatic diseases. | Available online http content 11 1 207 Review Transcription profiling of rheumatic diseases Lisa GM van Baarsen1 Carina L Bos1 Tineke CTM van der Pouw Kraan2 and Cornelis L Verweij1 3 1 Department of Pathology VU University Medical Center 1007 MB Amsterdam The Netherlands 2Department of Molecular Cell Biology and Immunology VU University Medical Center 1007 MB Amsterdam The Netherlands 3Department of Rheumatology VU University Medical Center 1007 MB Amsterdam The Netherlands Corresponding author Cornelis L Verweij Published 30 January 2009 This article is online at http content 11 1 207 2009 BioMed Central Ltd Arthritis Research Therapy 2009 11 207 doi ar2557 Abstract Rheumatic diseases are a diverse group of disorders. Most of these diseases are heterogeneous in nature and show varying responsiveness to treatment. Because our understanding of the molecular complexity of rheumatic diseases is incomplete and criteria for categorization are limited we mainly refer to them in terms of group averages. The advent of DNA microarray technology has provided a powerful tool to gain insight into the molecular complexity of these diseases this technology facilitates open-ended survey to identify comprehensively the genes and biological pathways that are associated with clinically defined conditions. During the past decade encouraging results have been generated in the molecular description of complex rheumatic diseases such as rheumatoid arthritis systemic lupus erythematosus Sjogren syndrome and systemic sclerosis. Here we describe developments in genomics research during the past decade that have contributed to our knowledge of pathogenesis and to the identification of biomarkers for diagnosis patient stratification and prognostication. Introduction Rheumatic diseases are a diverse group of disorders that involve the musculoskeletal system. Generally the cause of these disorders is unknown and their .
