Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Tissue engineering in the rheumatic diseases. | Available online http content 11 1 211 Review Tissue engineering in the rheumatic diseases Jochen Ringe and Michael Sittinger Tissue Engineering Laboratory and Berlin-Brandenburg Center for Regenerative Therapies Department of Rheumatology and Clinical Immunology Charité - Universitatsmedizin Berlin Tucholskystr. 2 10117 Berlin Germany Corresponding author Jochen Ringe Published 30 January 2009 This article is online at http content 11 1 211 2009 BioMed Central Ltd Arthritis Research Therapy 2009 11 211 doi ar2572 Abstract Diseases such as degenerative or rheumatoid arthritis are accompanied by joint destruction. Clinically applied tissue engineering technologies like autologous chondrocyte implantation matrix-assisted chondrocyte implantation or in situ recruitment of bone marrow mesenchymal stem cells target the treatment of traumatic defects or of early osteoarthritis. Inflammatory conditions in the joint hamper the application of tissue engineering during chronic joint diseases. Here most likely cartilage formation is impaired and engineered neocartilage will be degraded. Based on the observations that mesenchymal stem cells a develop into joint tissues and b in vitro and in vivo show immunosuppressive and anti-inflammatory qualities indicating a transplant-protecting activity these cells are prominent candidates for future tissue engineering approaches for the treatment of rheumatic diseases. Tissue engineering also provides highly organized three-dimensional in vitro culture models of human cells and their extracellular matrix for arthritis research. Introduction Diseases like rheumatoid arthritis RA or degenerative arthritis osteoarthritis OA are accompanied by a progressive reduction of extracellular matrices ECMs in joint cartilage and bone and eventually loss of joint function and excessive morbidity. Current pharmacological treatment of RA focuses on alleviating symptoms and or
