Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: What epidemiology has told us about risk factors and aetiopathogenesis in rheumatic diseases. | Available online http content 11 3 223 Review What epidemiology has told us about risk factors and aetiopathogenesis in rheumatic diseases Jacqueline E Oliver and Alan J Silman Arthritis Research Campaign Copeman House St Mary s Court St Mary s Gate Chesterfield Derbyshire S41 7TD UK Corresponding author Alan J Silman Published 19 May 2009 This article is online at http content 11 3 223 2009 BioMed Central Ltd Arthritis Research Therapy 2009 11 223 doi ar2585 Abstract This article will review how epidemiological studies have advanced our knowledge of both genetic and environmental risk factors for rheumatic diseases over the past decade. The major rheumatic diseases including rheumatoid arthritis juvenile idiopathic arthritis psoriatic arthritis ankylosing spondylitis systemic lupus erythematosus scleroderma osteoarthritis gout and fibromyalgia and chronic widespread pain will be covered. Advances discussed will include how a number of large prospective studies have improved our knowledge of risk factors including diet obesity hormones and smoking. The change from small-scale association studies to genome-wide association studies using gene chips to reveal new genetic risk factors will also be reviewed. Introduction This article will review epidemiological studies that have advanced the knowledge of both genetic and environmental risk factors for the rheumatic diseases outlining the major advances that have been achieved over the past decade Table 1 . It will focus on the following diseases rheumatoid arthritis RA juvenile idiopathic arthritis JIA psoriatic arthritis PsA ankylosing spondylitis AS systemic lupus erythematosus SLE scleroderma Scl osteoarthritis OA gout and fibromyalgia FM and chronic widespread pain CWP . A number of large prospective studies have improved our knowledge of risk factors the Framingham Study 1 and the Chingford 1000 Women Study 2 for OA the Nurses Health Study .
