Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized. | Available online http content 11 1 R11 Research article Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized David J Hunter1 2 Lou Gerstenfeld2 Gavin Bishop2 A David Davis2 Zach D Mason2 Tom A Einhorn2 Rose A Maciewicz3 Pete Newham3 Martyn Foster4 Sonya Jackson4 and Elise F Morgan2 Division of Research New England Baptist Hospital 1 25 Parker Hill Avenue Boston MA 02120 USA 2Orthopedic Department Boston University 715 Albany Street Boston MA 02118 USA 3Respiratory Inflammation AstraZeneca Macclesfield Cheshire SK10 4TF UK 4AstraZeneca R D Charnwood Loughborough Leicestershire LE11 5RH UK Corresponding author David J Hunter djhunter@ Received 30 Sep 2008 Revisions requested 6 Nov 2008 Revisions received 23 Dec 2008 Accepted 26 Jan 2009 Published 26 Jan 2009 Arthritis Research Therapy 2009 11 R11 doi ar2601 This article is online at http content 11 1 R11 2009 Hunter et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Although the presence of bone marrow lesions BMLs on magnetic resonance images is strongly associated with osteoarthritis progression and pain the underlying pathology is not well established. The aim of the present study was to evaluate the architecture of subchondral bone in regions with and without BMLs from the same individual using bone histomorphometry. Methods Postmenopausal female subjects n 6 age 48 to 90 years with predominantly medial compartment osteoarthritis and on a waiting list for total knee replacement were recruited. To identify the location of the BMLs subjects had a magnetic resonance imaging scan performed on their study .
