Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease. | Available online http content 11 1 R14 Research article The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease Ian D Welch1 Matthew F Cowan2 Frank Beier3 and Tully M Underhill2 1 Department of Animal Care and Veterinary Services University of Western Ontario London Ontario N6A 5C1 Canada 2Department of Cellular and Physiological Sciences The University of British Columbia Vancouver British Columbia V6T 1Z3 Canada department of Physiology and Pharmacology CIHR Group in Skeletal Development and Remodeling The University of Western Ontario London Ontario N6A 5C1 Canada Corresponding author Tully M Underhill tunderhi@ Received 12 Sep 2008 Revisions requested 12 Nov 2008 Revisions received 4 Dec 2008 Accepted 28 Jan 2009 Published 28 Jan 2009 Arthritis Research Therapy 2009 11 R14 doi ar2604 This article is online at http content 11 1 R14 2009 Welch et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Osteoarthritis OA is a debilitating disease with poorly defined aetiology. Multiple signals are involved in directing the formation of cartilage during development and the vitamin A derivatives the retinoids figure prominently in embryonic cartilage formation. In the present study we examined the expression of a retinoid-regulated gene in murine models of OA. Methods Mild and moderate forms of an OA-like degenerative disease were created in the mouse stifle joint by meniscotibial transection MTX and partial meniscectomy PMX respectively. Joint histopathology was scored using an Osteoarthritis Research Society International OARSI system and gene expression Collal Col10a1 Sox9 and Crabp2 in
