Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Heavy metal exposure reverses genetic resistance to Chlamydia-induced arthritis. | Available online http content 11 1 R19 Research article Heavy metal exposure reverses genetic resistance to Chlamydia-induced arthritis Robert D Inman1 2 and Basil Chiu1 2 Division of Genes and Development Toronto Western Research Institute 399 Bathurst Street Toronto ON M5T 2S8 Canada 2Department of Medicine University of Toronto 190 Elizabeth Street Toronto ON M5G 2C4 Canada Corresponding author Robert D Inman Received 9 Aug 2008 Revisions requested 10 Sep 2008 Revisions received 19 Dec 2008 Accepted 9 Feb 2009 Published 9 Feb 2009 Arthritis Research Therapy 2009 11 R19 doi ar2610 This article is online at http content 11 1 R19 2009 Inman and Chiu licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction We have previously observed that Brown Norway BN rats display a relative resistance to experimental Chlamydia- mduced arthritis. In the present study we examine an environmental toxin mercuric chloride HgCl2 as a modulator of this innate resistance to arthritis. Methods To assess the effect of the heavy metal exposure one group of rats received two subcutaneous injections of HgCl2 1 mg kg 48 hours apart. Seven days later the animals received the intra-articular injection of synoviocyte-packaged Chlamydia. Results Histopathology revealed that BN rats receiving only Chlamydia had a minimal cellular infiltration in the joint which was predominantly mononuclear in character. In contrast mercury-exposed rats had a marked exacerbation of the histopathological severity of the arthritis and the infiltration was predominantly neutrophilic. Mercury exposure was also associated with marked enhancement in IgE levels and an alteration
