Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Blockade of lymphotoxin-beta receptor signaling reduces aspects of Sjögren's syndro. | Available online http content 11 1 R24 Research article Blockade of lymphotoxin-beta receptor signaling reduces aspects of Sjogren s syndrome in salivary glands of non-obese diabetic mice Margaret K Gatumu1 Kathrine Skarstein1 Adrian Papandile2 Jeffrey L Browning2 Roy A Fava3 4 and Anne Isine Bolstad5 Section for Pathology The Gade Institute University of Bergen Haukeland University Hospital Jonas Lies vei 65 N-5021 Bergen Norway 2Department of Immunobiology Biogen Idec 12 Cambridge Center Cambridge MA 02142 USA 3Department of Veterans Affairs Medical Center 215 North Main Street White River Junction VT 05009 USA 4Department of Micro Immunology Dartmouth Medical School 1 Rope Ferry Road Hanover NH 03756 USA 5Department of Clinical Dentistry - Periodontics University of Bergen Aarstadveien 17 N-5009 Bergen Norway Corresponding author Anne Isine Bolstad Received 18 Dec 2008 Revisions requested 13 Jan 2009 Revisions received 30 Jan 2009 Accepted 18 Feb 2009 Published 18 Feb 2009 Arthritis Research Therapy 2009 11 R24 doi ar2617 This article is online at http content 11 1 R24 2009 Gatumu et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The lymphotoxin-beta receptor LTpR pathway is important in the development and maintenance of lymphoid structures. Blocking this pathway has proven beneficial in murine models of autoimmune diseases such as diabetes and rheumatoid arthritis. The aim of this study was to determine the effects of LTpR pathway blockade on Sjogren syndrome SS -like salivary gland disease in non-obese diabetic NOD mice. Methods The course of SS-like disease was followed in NOD mice that were given .
