Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: In vivo imaging approaches in animal models of rheumatoid arthritis. | Available online http content 5 4 165 Review In vivo imaging approaches in animal models of rheumatoid arthritis Michael L Dustin Skirball Institute of Biomolecular Medicine and Department of Pathology New York University School of Medicine New York USA Corresponding author Michael L Dustin e-mail dustin@ Received 14 Nov 2002 Revisions requested 29 Nov 2002 Revisions received 4 Apr 2003 Accepted 10 Apr 2003 Published 1 May 2003 Arthritis Res Ther 2003 5 165-171 DOI ar768 2003 BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 Abstract The interaction of activated leukocytes with the rheumatoid synovial environment is a key process in arthritis. Understanding this process will play an important role in designing effective treatments. In vivo imaging approaches combined with molecular genetics in animal models provide important tools to address these issues. The present review will focus on approaches to in vivo imaging with particular attention to approaches that are proving useful for or have promise for research on animal models of rheumatoid arthritis. These approaches will probably shed light on the specific local mechanisms involved in chronic inflammation and provide real time monitoring approaches to follow cellular and molecular events related to disease development. Keywords arthritis fluorescence imaging luminescence microscopy Introduction the in vivo renaissance The early phase of exploration of the lymphoid system generated a wealth of information about anatomy and in vivo responses. Our ability to define molecular structures in the context of the anatomy of the in vivo immune response first with antibodies and more recently with tools of molecular genetics has increased the ability to incisively test hypotheses through in vivo experimentation. This is leading to a renaissance in a variety of in vivo studies mostly focused around genetic manipulations. The molecular genetics tools are also .
