Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Leukotrienes, mast cells, and T cells. | Arthritis Research Therapy Vol 5 No 6 Mclnnes Viewpoint Leukotrienes mast cells and T cells lain B Mclnnes Centre for Rheumatic Diseases University of Glasgow Scotland UK Correspondence Iain B McInnes e-mail Received 26 Sep 2003 Accepted 1 Oct 2003 Published 15 Oct 2003 Arthritis Res Ther 2003 5 288-289 DOI ar1017 2003 BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 Unravelling the complex interactions that regulate the recruitment and subsequent cellular crosstalk between leukocyte subsets in inflamed synovium offers considerable therapeutic potential. In rheumatoid arthritis RA synovial membrane is characterised by T-cell infiltrates including both CD4 and CD8 subsets that occupy distinct domains within the tissue 1 2 . The former have attracted the most attention given their proposed central role in the development and maintenance of acquired immune responses in the synovium. Their functional importance however has been critically reviewed particularly in light of equivocal or negative outcomes in clinical trials in which CD4 T cells have been specifically targeted 1 3 4 . Thus far only CTLA4-Ig has shown any clinical promise 5 . Although comprising up to 40 of the synovial T-cell compartment CD8 T cells have received less attention. CD8 T cells are widely distributed throughout the synovial membrane and in synovial fluid exhibit an activated phenotype and enhanced migratory activity express proinflammatory cytokines and contribute to formation of ectopic germinal centres in synovial tissues 1 6 7 . Recruitment of CD8 T cells to the synovial compartment has been considered a function of appropriate chemokine gradients lymphocyte chemokine receptor expression and activation of endothelial cells expressing adhesion molecules. Antigen-experienced CD8 T cells segregate into at least two populations in mice namely central memory CD8 T cells Tcm CD62Lhi CCR7hi which traffic primarily to lymphoid tissues and effector
