Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Citrullination, a possible functional link between susceptibility genes and rheumatoid arthritis. | Available online http content 6 1 1 Commentary Citrullination a possible functional link between susceptibility genes and rheumatoid arthritis Erik R Vossenaar Albert JW Zendman and Walther J van Venrooij Department of Biochemistry University of Nijmegen The Netherlands Corresponding author Erik R Vossenaar e-mail Received 18 Sep 2003 Accepted 23 Oct 2003 Published 25 Nov 2003 Arthritis Res Ther 2004 6 1-5 DOI ar1027 2004 BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 Abstract Antibodies directed to citrullinated proteins anti-eyelie citrullinated peptide are highly specific for rheumatoid arthritis RA . Recent data suggest that the antibodies may be involved in the disease process of RA and that several RA-associated genetic factors might be functionally linked to RA via modulation of the production of anti-cyclic citrullinated peptide antibodies or citrullinated antigens. Keywords anti-cyclic citrullinated peptide autoantibodies citrullination genetic susceptibility peptidylarginine deiminase rheumatoid arthritis Introduction The serum of rheumatoid arthritis RA patients contains a variety of antibodies directed against self-antigens. The most widely known of these autoantibodies is the rheumatoid factor antibodies directed against the constant domain of IgG molecules reviewed in 1 . The rheumatoid factor can not only be detected in roughly 75 of RA patients but also in the serum of patients with other rheumatic or inflammatory diseases and even in a substantial percentage of the healthy elderly population 2 . Its presence is therefore not very specific for RA. Autoantibodies directed against citrullinated proteins have a much higher specificity for RA reviewed in 3 . This family of autoantibodies includes the anti-perinuclear factor the so-called anti- keratin antibodies anti-filaggrin antibodies anti-cyclic citrullinated peptide anti-CCP antibodies and probably also anti-Sa antibodies for .
