Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Relationship between radiographic grading of osteoarthritis and the biochemical markers for arthritis in knee osteoarthritis. | Arthritis Research Therapy Vol 6 No 3 Takahashi et al. Research article Open Access Relationship between radiographic grading of osteoarthritis and the biochemical markers for arthritis in knee osteoarthritis Masaaki Takahashi Kenichi Naito Masashi Abe Tomokazu Sawada and Akira Nagano Department of Orthopaedic Surgery Hamamatsu University School of Medicine Hamamatsu Japan Corresponding author Masaaki Takahashi e-mail taka1m@ Received 10 Dec 2003 Revisions requested 14 Jan 2004 Revisions received 12 Feb 2004 Accepted 24 Feb 2004 Published 12 Mar 2004 Arthritis Res Ther 2004 6 R208-R212 DOI ar1166 2004 Takahashi et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract The aim of this study was to investigate the relationship between the biochemical markers of arthritis and the radiographic grading of osteoarthritis OA in knees. Seventy-one women aged 49-85 years with knee OA were studied. Anterior-posterior knee radiographs and hand radiographs were taken in all patients. The radiographic grading of OA in the knee was performed by using the Kellgren-Lawrence criteria and the joint space width. The 71 patients with knee OA were divided into two groups 37 patients exhibiting generalized osteoarthritis GOA and 34 non-GOA patients according to the grading of their hand radiograph. C-reactive protein CRP urinary pyridinoline YKL-40 plasma matrix metalloproteinase MMP -3 MMP-9 and tissue inhibitor of metalloproteinases TIMP -1 were measured as the biochemical markers of arthritis. The radiographic grading with the Kellgren-Lawrence scale revealed a significant relationship to the joint space width P the joint space width decreased with increasing Kellgren-Lawrence grade. All biochemical markers had negative correlations with the joint space width but only .
