Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice. | Available online http content 6 3 R256 Research article Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice Eiva Bernotiene1 2 Gaby Palmer1 Dominique Talabot-Ayer1 Ildiko Szalay-Quinodoz3 Michel L Aubert4 and Cem Gabay1 Division of Rheumatology University Hospital and Department of Pathology University of Geneva School of Medicine Geneva Switzerland 2Department of Immunology Institute of Experimental and Clinical Medicine at Vilnius University Vilnius Lithuania 3Division of Clinical Pathology University Hospital Geneva Switzerland 4Division of Development and Growth Department of Pediatrics University of Geneva School of Medicine Geneva Switzerland Corresponding author Cem Gabay Received 09 Jul 2003 Revisions requested 11 Aug 2003 Revisions received 3 Mar 2004 Accepted 15 Mar 2004 Published 26 Apr 2004 Arthritis Res Ther 2004 6 R256-R263 DOI ar1174 2004 Bernotiene etal. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Open Access Abstract The severity of antigen-induced arthritis AIA is decreased in leptin-deficient ob ob mice. However joint inflammation in AIA depends on the immune response which is impaired in ob ob mice. In the present study we investigated the effects of leptin deficiency on zymosan-induced arthritis ZIA which is independent of adaptive immunity. Arthritis was induced by injection of zymosan into the knee joint. Joint swelling was similar after 6 and 24 hours in ob ob and control mice. However it remained elevated in ob ob animals on day 3 whereas values normalized in controls. Histology revealed similar articular lesions in all animals on day 3 but on days 14 and 21 arthritis tended to be more severe in ob ob mice. The acute phase response reflected by circulating levels .
