Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor. | Available online http content 6 4 R309 Research article Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor 1 Yannick Allanore1 Didier Borderie2 Hervé Lemaréchal2 Ohvanesse Garabed Ekindjian2 and André Kahan1 1Paris V University Department of Rheumatology A Assistance Publique Hôpitaux de Paris Cochin Hospital Paris France 2Department of Biochemistry A Assistance Publique Hôpitaux de Paris Cochin Hospital Paris France Corresponding author Yannick Allanore Received 31 Jan 2004 Revisions requested 4 Mar 2004 Revisions received 22 Mar 2004 Accepted 2 Apr 2004 Published 1 2 May 2004 Arthritis Res Ther 2004 6 R309-R314 DOI ar1183 2004 Allanore et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Open Access Abstract Microvascular injury oxidative stress and impaired angiogenesis are prominent features of systemic sclerosis SSc . We compared serum markers of these phenomena at baseline and after treatment with nifedipine in SSc patients. Forty successive SSc patients were compared with 20 matched healthy subjects. All SSc patients stopped taking calcium-channel blockers 72 hours before measurements. Twenty SSc patients were also examined after 14 days of treatment with nifedipine 60 mg day . Quantitative ELISA was used to measure the serum concentrations of vascular endothelial growth factor VEGF soluble VEGF receptor 1 sVEGFR-1 soluble vascular cell adhesion molecule 1 sVCAM-1 carbonyl residues and advanced oxidation protein products AOPP . The median concentrations of VEGF sVEGFR-1 sVCAM-1 carbonyl residues and AOPP were significantly higher in SSc Keywords nifedipine oxidative stress .
