Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: What should be the core outcomes in chronic pain clinical trials? | Available online http content 6 4 151 Commentary What should be the core outcomes in chronic pain clinical trials Dennis C Turk1 and Robert H Dworkin2 1 Department of Anesthesiology University of Washington Seattle Washington USA 2Department of Anesthesiology University of Rochester New York USA Corresponding author Dennis C Turk turkdc@ Received 25 Feb 2004 Revisions requested 11 May 2004 Revisions received 13 May 2004 Accepted 13 May 2004 Published 4 Jun 2004 Arthritis Res Ther 2004 6 151-154 DOI ar1196 2004 BioMed Central Ltd Abstract A consensus conference with representatives from academia governmental agencies and the pharmaceutical industry met and concluded that clinical trials designed to assess the efficacy and effectiveness of treatments for chronic pain should consider outcomes in six core domains pain physical functioning emotional functioning patient global ratings of satisfaction negative health states and adverse events and patient disposition. In addition it was acknowledged that there are many secondary domains that might be of importance and should be included in trials depending on the nature of the treatment and population to whom the treatment is targeted. Keywords chronic pain clinical trials outcomes patient global ratings quality of life Introduction Precise estimates of the prevalence of different pain syndromes in the USA are difficult to ascertain however there might be more than 30 million people with chronic or recurrent painful conditions. Nearly one-half of Americans who seek treatment with a physician report that their primary symptom is pain. This makes pain the single most frequent reason for physician consultation in the United States 1 . The US National Health Interview Survey determined that in the three-month period before the interview 28 had experienced pain in the lower back 16 experienced a severe headache 15 had experienced pain in the neck region and 4 had experienced pain .
