Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Signaling by STATs. | Available online http content 6 4 159 Review Signaling by STATs Lionel B Ivashkiv and Xiaoyu Hu Arthritis and Tissue Degeneration Program Hospital for Special Surgery Graduate Program in Immunology Weill Graduate School of Medical Sciences of Cornell University New York New York USA Corresponding author Lionel B Ivashkiv ivashkivl@ Received 16 Apr 2004 Accepted 18 May 2004 Published 21 Jun 2004 Arthritis Res Ther 2004 6 159-168 DOI ar1197 2004 BioMed Central Ltd Abstract A variety of cytokines and growth factors use the Janus kinase Jak -STAT signaling pathway to transmit extracellular signals to the nucleus. STATs signal transducers and activators of transcription are latent cytoplasmic transcription factors. There are seven mammalian STATs and they have critical nonredundant roles in mediating cellular transcriptional responses to cytokines. The physiological roles of STATs have been elucidated by analysis of mice rendered deficient in STAT genes. STAT activation is regulated and can be modulated in a positive or negative fashion it can be reprogrammed to drive different cellular responses. Several auto-regulatory and signaling crosstalk mechanisms for regulating Jak-STAT signaling have been described. Understanding and manipulation of the function of STATs will help in the development of therapeutic strategies for diseases that are regulated by cytokines. Keywords cytokine inhibition Jak signal transduction STAT Basic Jak-STAT signaling Cytokines are proteins that are secreted and mediate communication between cells. The biological functions of cytokines are achieved by binding with high affinity and specificity to cell-surface receptors thereby triggering signal transduction cascades that regulate cellular activation proliferation differentiation and survival. Many if not most cytokines use the Janus kinase Jak -signal transducer and activator of transcription STAT signaling pathway to mediate gene activation or repression.
