Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate. | Available online http content 6 5 R447 Research article Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjogren s syndrome relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate Michele Bombardieri1 2 Francesca Barone1 2 Valerio Pittoni2 Cristiano Alessandri2 Paola Conigliaro2 Mark C Blades1 Roberta Priori2 Iain B Mclnnes3 Guido Valesini2 and Costantino Pitzalis1 Rheumatology Department GKT School of Medicine King s College London UK 2Cattedra di Reumatologia Dipartimento di Clinica e Terapia Medica Applicata Universita di Roma La Sapienza Italy 3Centre for Rheumatic Diseases University of Glasgow UK Corresponding author Costantino Pitzalis Received 2 Apr 2004 Revisions requested 29 Apr 2004 Revisions received 26 May 2004 Accepted 10 Jun 2004 Published 3 Aug 2004 Arthritis Res Ther 2004 6 R447-R456 DOI ar1 209 2004 Bombardieri et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Open Access Abstract IL-18 an immunoregulatory and proinflammatory cytokine has been shown to play an important pathogenic role in Th1-driven autoimmune disorders. In this study we evaluated the circulating levels and salivary-gland expression of IL-18 in patients with Sjogren s syndrome SS a mainly Th1-mediated disease. IL-18 serum levels were measured by ELISA in 37 patients with primary SS 42 with rheumatoid arthritis and 21 normal controls. We demonstrated high IL-18 serum levels in SS similar to those in rheumatoid arthritis patients and significantly higher than in controls P . In addition IL-18 serum concentrations were significantly higher in anti-SSA Ro and anti-SSB La than in anti-SSA Ro and anti-SSB La SS patients respectively P P .
