Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells. | Available online http content 6 6 R544 Research article Collagen type II Cll -specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells Kutty Selva Nandakumar Johan Backlund Mikael Vestberg and Rikard Holmdahl Section for Medical Inflammation Research Lund University Sweden Corresponding author Kutty Selva Nandakumar nan@ Received 11 May 2004 Revisions requested 26 May 2004 Revisions received 16 Jun 2004 Accepted 30 Jun 2004 Published 23 Sep 2004 Arthritis Res Ther 2004 6 R544-R550 DOI ar1217 2004 Nandakumar et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Open Access Abstract Antibodies against type II collagen anti-CII are arthritogenic and have a crucial role in the initiation of collagen-induced arthritis. Here we have determined the dependence of T and B cells in collagen-antibody-induced arthritis CAIA during different phases of arthritis. Mice deficient for B and or T cells were susceptible to the CAIA showing that the antibodies induce arthritis even in the absence of an adaptive immune system. To determine whether CII-reactive T cells could have a role in enhancing arthritis development at the effector level of arthritis pathogenesis we established a T cell line reactive with CII. This T cell line was oligoclonal and responded to different post-translational forms of the major CII epitope at position 260-270 bound to the Aq class II molecule. Importantly it crossreacted with the mouse peptide although it is bound with lower affinity to the Aq molecule than the corresponding rat peptide. The T cell line could not induce clinical arthritis per se in Aq-expressing mice even if these mice expressed the .