Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2. | Available online http content 6 5 215 Review Regulating the immune system the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2 Diabetes Program Benaroya Research Institute at Virginia Mason Seattle Washington USA 2Immunology Program Benaroya Research Institute at Virginia Mason Seattle Washington USA Corresponding author Steven F Ziegler sziegler@ Received 31 Mar 2004 Revisions requested 12 May 2004 Revisions received 19 Jul 2004 Accepted 21 Jul 2004 Published 11 Aug 2004 Arthritis Res Ther 2004 6 215-222 DOI ar1226 2004 BioMed Central Ltd Abstract The immune system has evolved a variety of mechanisms to achieve and maintain tolerance both centrally and in the periphery. Central tolerance is achieved through negative selection of autoreactive T cells while peripheral tolerance is achieved primarily via three mechanisms activation-induced cell death anergy and the induction of regulatory T cells. Three forms of these regulatory T cells have been described those that function via the production of the cytokine IL-10 T regulatory 1 cells transforming growth factor beta Th3 cells and a population of T cells that suppresses proliferation via a cell-contact-dependent mechanism CD4 CD25 TR cells . The present review focuses on the third form of peripheral tolerance - the induction of regulatory T cells. The review will address the induction of the three types of regulatory T cells the mechanisms by which they suppress T-cell responses in the periphery the role they play in immune homeostasis and the potential these cells have as therapeutic agents in immune-mediated disease. Keywords interleukin-10 regulatory T cell suppression transforming growth factor beta tolerance Introduction The ability of the immune system to distinguish between self-antigens and nonself-antigens and between harmful and innocuous foreign antigens is critical to the maintenance of immune homeostasis. Failure to .
