Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Resistance to IL-10 inhibition of interferon gamma production and expression of suppressor of cytokine signaling 1 in CD4+ T cells from patients with rheumatoid arthritis. | Available online http content 6 6 R567 Research article Resistance to IL-10 inhibition of interferon gamma production and expression of suppressor of cytokine signaling 1 in CD4 T cells from patients with rheumatoid arthritis Jiro Yamana Masahiro Yamamura Akira Okamoto Tetsushi Aita Mitsuhiro Iwahashi Katsue Sunahori and Hirofumi Makino Department of Medicine and Clinical Science Graduate School of Medicine and Dentistry Okayama University Okayama Japan Corresponding author Masahiro Yamamura yamamura@ Received 26 May 2004 Revisions requested 1 Jul 2004 Revisions received 20 Jul 2004 Accepted 25 Aug 2004 Published 13 Oct 2004 Arthritis Res Ther 2004 6 R567-R577 DOI ar1445 2004 Yamana et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Open Access Abstract IL-10 has been shown to block the antigen-specific T-cell cytokine response by inhibiting the CD28 signaling pathway. We found that peripheral blood CD4 T cells from patients with active rheumatoid arthritis RA were able to produce greater amounts of interferon gamma after CD3 and CD28 costimulation in the presence of 1 ng ml IL-10 than were normal control CD4 T cells although their surface expression of the type 1 IL-10 receptor was increased. The phosphorylation of signal transducer and activator of transcription 3 was sustained in both blood and synovial tissue CD4 T cells of RA but it was not augmented by the presence of 1 ng ml IL-10. Sera from RA patients induced signal transducer and activator of transcription 3 phosphorylation in normal CD4 T cells which was mostly abolished by neutralizing anti-IL-6 antibody. Preincubation of normal CD4 T cells with IL-6 reduced IL-10-mediated inhibition of interferon gamma production. .
