Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Gastrointestinal stromal tumors: correlation between symptoms at presentation, tumor location and prognostic factors in 47 consecutive patients | WORLD JOURNAL OF SURGICAL ONCOLOGY Gastrointestinal stromal tumors correlation between symptoms at presentation tumor location and prognostic factors in 47 consecutive patients Caterino et al. Caterino et al. World Journal of Surgical Oncology 2011 9 13 http content 9 1 13 1 February 2011 BioMed Central Caterino et al. World Journal of Surgical Oncology 2011 9 13 http content 9 1 13 5 2 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Gastrointestinal stromal tumors correlation between symptoms at presentation tumor location and prognostic factors in 47 consecutive patients 1 1 1 2 3 4 Salvatore Caterino Laura Lorenzon Niccolò Petrucciani Elsa lannicelli Emanuela Pilozzi Adriana Romiti Marco Cavallini 1 Vincenzo Ziparo1 Abstract Background Gastrointestinal stromal tumors GIST are mesenchymal tumors of the gastrointestinal tract usually kit-positive that are believed to originate from interstitial cell of Cajal or their related stem cells. The most common clinical presentation of these tumors is gastrointestinal bleeding otherwise they may cause intestinal obstruction abdominal pain a palpable mass or can be incidentally detected during surgery or endoscopic radiological procedures. Prognosis is related to the size of the tumor and to the mitotic rate other prognostic factors are tumor location tumor resection margins tumor rupture and c-kit mutation that may interfere with molecular target therapy efficacy. Aim Primary aim of this study was to report our experience regarding GIST patients correlating symptoms at presentation with tumor localization and risk factors. Patients and methods 47 consecutive patients undergone to surgical resection for GISTs were enrolled in a prospective study from December 1999 to March 2009. Patient s clinical and pathological features were collected and analysed. Results The most common symptom was abdominal pain. Bleeding in the digestive tract and abdominal pain were more frequent in gastric GISTs 58
