Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Primary malignant mixed müllerian tumor of the peritoneum a case report with review of the literature | Kurshumliu et al. World Journal of Surgical Oncology 2011 9 17 http content 9 1 17 7 WORLD JOURNAL OF SURGICAL ONCOLOGY CASE REPORT Open Access Primary malignant mixed mullerian tumor of the peritoneum a case report with review of the literature Fisnik Kurshumliu1 Helle Rung-Hansen2 Vibeke Ravn Skovlund3 Lumturije Gashi-Luci1 Thomas Horn3 Abstract Malignant mixed Mullerian tumor is a rare malignancy of the genital tract and extremely uncommon in extragenital sites. This report describes a case of malignant mixed Mullerian tumor arising in the lower peritoneum of a 72-year-old female patient. The patient presented with ascites lower abdominal mass and pleural effusion. The serum level of CA125 was elevated. At operation a diffuse carcinosis associated with tumor mass measuring 20 X 15 X 10 cm in the vesicouterine and Duglas pouch were found. The uterus and the adnexa were unremarkable. Histopathology revealed a typical malignant mixed Mullerian tumor heterologous type. The epithelial component was positive for cytokeratin 7 and vimentin whereas the mesenchymal component was positive for Vimentin S100 and focally for CK7. The histogenesis of this tumor arising from the peritoneum is still speculative. Based on the previous reports and the immunohistochemical analysis of our case we believe that this is a monoclonal tumor with carcinoma being the precursor element. Nevertheless further molecular and genetic evidence is needed to support such a conclusion. Background Malignant mixed Mullerian tumor MMMT is a rare entity that arises from structures that are embryologically related to the Mullerian system 1 2 . The usual location of MMMT is the female genital tract. Extragenital origin is extremely rare 3-5 . Histologically and by immunohistochemistry the tumor exhibits both epithelial and mesenchymal components. Since the first report in 1955 by Ober and Black 5 to our knowledge there have been only 30 well documented reports of extragenital malignant mixed
