Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Multimodality treatment of brain metastases: an institutional survival analysis of 275 patients | Elaimy et al. World Journal of Surgical Oncology 2011 9 69 http content 9 1 69 2 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Multimodality treatment of brain metastases an institutional survival analysis of 275 patients 12 12 12 14 Ameer L Elaimy Alexander R Mackay Wayne T Lamoreaux Robert K Fairbanks John J Demakas Barton S Cooke1 Benjamin J Peressini5 John T Holbrook2 and Christopher M Lee1 2 Abstract Background Whole brain radiation therapy WBRT surgical resection stereotactic radiosurgery SRS and combinations of the three modalities are used in the management of patients with metastatic brain tumors. We present the previously unreported survival outcomes of 275 patients treated for newly diagnosed brain metastases at Cancer Care Northwest and Gamma Knife of Spokane between 1998 and 2008. Methods The effects treatment regimen age Eastern Cooperative Oncology Group-Performance Status ECOG-PS primary tumor histology number of brain metastases and total volume of brain metastases have on patient overall survival were analyzed. Statistical analysis was performed using Kaplan-Meier survival curves Andersen 95 confidence intervals approximate confidence intervals for log hazard-ratios and multivariate Cox proportional hazard models. Results The median clinical follow up time was months. On multivariate analysis survival statistically favored patients treated with SRS alone when compared to patients treated with WBRT alone p patients treated with resection with SRS when compared to patients treated with SRS alone p patients in ECOG-PS class 0 when compared to patients in ECOG-PS classes 2 p 3 p and 4 p patients in the nonsmall-cell lung cancer group when compared to patients in the combined melanoma and renal-cell carcinoma group p and patients with breast cancer when compared to patients with non-small-cell lung cancer p . Conclusions In our analysis patients benefited from a combined modality .
