Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Littoral cell angioma of the spleen in a patient with previous pulmonary sarcoidosis: a TNF-α related pathogenesis? | Cordesmeyer et al. World Journal of Surgical Oncology 2011 9 106 http content 9 1 106 5 WORLD JOURNAL OF SURGICAL ONCOLOGY CASE REPORT Open Access Littoral cell angioma of the spleen in a patient with previous pulmonary sarcoidosis a TNF-a related pathogenesis Stefanie Cordesmeyer1 2 Manfred Putzler3 Ulf Titze4 Harald Paulus5 and Matthias W Hoffmann2 Abstract Background Littoral cell angioma LCA is a rare vascular tumor of the spleen. Generally thought to be benign additional cases of LCA with malignant features have been described. Thus its malignant potential seems to vary and must be considered uncertain. The etiology remains unclear but an immune dysregulation for the apparent association with malignancies of visceral organs or immune-mediated diseases has been proposed. Case Presentation We report a case of LCA in a 43-year old male patient who presented with a loss of appetite and intermittent upper abdominal pain. Computed tomography showed multiple hypoattenuating splenic lesions which were hyperechogenic on abdominal ultrasound. Lymphoma was presumed and splenectomy was performed. Pathological evaluation revealed LCA. Conclusions LCA is a rare primary vascular neoplasm of the spleen that might etiologically be associated with immune dysregulation. In addition it shows a striking association with synchronous or prior malignancies. With about one-third of the reported cases to date being co-existent with malignancies of visceral organs or immune-mediated diseases this advocates for close follow-ups in all patients diagnosed with LCA. To our knowledge this report is the first one of LCA associated with previous pulmonary sarcoidosis and hypothesizes a TNF-a related pathogenesis of this splenic tumor. Keywords Splenic tumor littoral cell angioma visceral organ malignancies sarcoidosis TNF-a Background Vascular tumors are the most common primary neoplasms of the spleen. Among these LCA is a very rare tumor which arises from the littoral cells .
