Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Influence of viral hepatitis status on prognosis in patients undergoing hepatic resection for hepatocellular carcinoma: a meta-analysis of observational studies | Zhou et al. World Journal of Surgical Oncology 2011 9 108 http content 9 1 108 5 t WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Influence of viral hepatitis status on prognosis in patients undergoing hepatic resection for hepatocellular carcinoma a meta-analysis of observational studies 1 2 1 -1 1 3 Yanming Zhou Xiaoying Si Lupeng Wu Xu Su Bin Li and Zhiming Zhang Abstract Background The influence of viral hepatitis status on prognosis in patients undergoing hepatic resection for hepatocellular carcinoma HCC remains a matter of debate. This study is a meta-analysis of the available evidence. Methods A literature search was performed to identify comparative studies reporting postoperative survival of HCC in different types of viral hepatitis. Pooled odds ratios OR and weighted mean differences WMD with 95 confidence intervals 95 CI were calculated using either the fixed effects model or random effects model. Results Twenty studies matched the selection criteria and reported on 4744 subjects of whom 2008 in the HBV-positive B-HCC group 2222 in the HCV-positive C-HCC group and 514 in the hepatitis B- and C-negative NBNC-HCC . Meta-analysis showed that patients with HBV or HCV infection had a worse 5-year disease-free survival when compared to patients with NBNC-HCC respectively OR 95 CI to P WMD 95 CI to P . There was a tendency toward higher 5-year overall survival rates in the NBNC-HCC group compared to those in the other two groups although these differences were not statistically significant. Both the 5-year overall survival and disease-free survival were not different among the B-HCC and C-HCC groups. Conclusions Patients with positive serology for hepatitis B or C undergoing resection for HCC had a poor prognosis compared to patients with negative serology. Keywords Hepatocellular carcinoma Viral infection Hepatitis B Hepatitis C Prognosis Background Hepatocellular carcinoma HCC is the fifth most
