Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Can primary optimal cytoreduction be predicted in advanced epithelial ovarian cancer preoperatively? | Mousavi et al. World Journal of Surgical Oncology 2010 8 11 http content 8 1 11 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Can primary optimal cytoreduction be predicted in advanced epithelial ovarian cancer preoperatively Azam-Sadat Mousavi Marjan Moradi Mazhari Mitra Modares Guilani Fatemeh Ghaemmaghami Nadereh Behtash Setareh Akhavan Abstract Introduction Prediction of optimal cytoreduction in patients with advanced epithelial ovarian caner preoperatively. Methods Patients with advanced epithelial ovarian cancer who underwent surgery for the first time from Jan. to June 2008 at gynecologic oncology ward of TUMS Tehran University of Medical Sciences were eligible for this study. The possibility of predicting primary optimal cytoreduction considering multiple variables was evaluated. Variables were peritoneal carcinomatosis serum CA125 ascites pleural effusion physical status and imaging findings. Univariate comparisons of patients underwent suboptimal cytoreduction carried out using Fisher s exact test for each of the potential predictors. The wilcoxon rank sum test was used to compare variables between patients with optimal versus suboptimal cytoreduction. Results 41 patients met study inclusion criteria. Statistically significant association was noted between peritoneal carcinomatosis and suboptimal cytoreduction. There were no statistically significant differences between physical status pleural effusion imaging findings serum CA125 and ascites of individuals with optimal cytoreduction compared to those with suboptimal cytoreduction. Conclusions Because of small populations in our study the results are not reproducible in alternate populations. Only the patient who is most unlikely to undergo optimal cytoreduction should be offered neoadjuvant chemotherapy unless her medical condition renders her unsuitable for primary surgery. Introduction Ovarian cancer is the leading cause of morbidity and mortality among the gynecologic cancers 1
