Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Intraductal papillary mucinous neoplasm of the pancreas (IPMN): clinico-pathological correlations and surgical indications | Baiocchi et al. World Journal of Surgical Oncology 2010 8 25 http content 8 1 25 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Intraductal papillary mucinous neoplasm of the pancreas IPMN clinico-pathological correlations and surgical indications 1 1 2 3 1 1 Gian Luca Baiocchi Nazario Portolani Guido Missale Carla Baronchelli Federico Gheza Massimiliano Cantù Luigi Grazioli4 Stefano M Giulini1 Abstract Background Intraductal papillary mucinous neoplasms IPMNs are increasingly recognized entities whose management remains sometimes controversial due to the high rate of benign lesions and on the other side to the good survival after resection of malignant ones. Methods Retrospective analysis of a prospectively collected Western series of IPMN. Results Forty cases of IPMN were analysed 1992-2007 . Most patients were symptomatic cholangio-MRI had the best diagnostic accuracy both for the tumour nature and for the presence of malignancy . ERCP was done in 8 cases 20 and the results were poor. Thirteen patients were treated by pancreatic resection and 27 were maintained in follow-up. Total pancreatectomy was performed in 46 of the cases in situ and invasive carcinoma were recognized in and of the cases respectively. The mean follow-up was 42 months range 12-72 . One only patients with nodal metastases died 16 months after the operation for disease progression while of the operated patients are disease free. Out of the 27 not resected patients 2 out of 4 presenting a lesion at high risk for malignancy died while the remaining are in good conditions and disease free with a mean follow-up of 31 months. Conclusion Therapeutic indication for IPMNs is mainly based upon radiological evaluation of the risk of malignancy. While the main duct tumours should be resected preserving whenever possible a portion of the gland the secondary ducts tumours may be maintained under observation in absence of radiological elements of .
