Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Human vascular adhesion proteın-1 (VAP-1): Serum levels for hepatocellular carcinoma in non-alcoholic and alcoholic fatty liver disease | Kemik et al. World Journal of Surgical Oncology 2010 8 83 http content 8 1 83 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Human vascular adhesion protein-1 VAP-1 Serum levels for hepatocellular carcinoma in non-alcoholic and alcoholic fatty liver disease 1 A 1 2 1 3 I- n 4 5 Ozgur Kemik Aziz Sumer Ahu Sarbay Kemik Veyis Itik Ahmet Cumhur Dulger Sevim Purisa Sefa Tuzun Abstract Background The incidence of hepatocellular cancer in complicated alcoholic and non-alcoholic fatty liver diseases is on the rise in western countries as well in our country. Vascular adhesion protein-1 VAP-1 levels have been presented as new marker. In our study protocol we assessed the value of this serum protein as a newly postulant biomarker for hepatocellular cancer in patients with a history of alcoholic and non-alcoholic fatty liver diseases. Methods Pre-operative serum samples from 55 patients with hepatocellular cancer with a history of alcoholic and non-alcoholic fatty liver diseases and patients with cirrhosis were assessed by a quantitative sandwich ELISA using anti-VAP-1 mAbs. This technique is used to determine the levels of soluble VAP-1 sVAP-1 in the serum. Results sVAP-1 levels were evaluated in patients with hepatocellular cancer and liver cirrhosis. There was a significant difference in mean VAP-1 levels between groups. Serum VAP-1 levels were found higher in patients with hepatocellular cancer. Conclusion These findings indicate that the serum level of sVAP-1 might be a beneficial marker of disease activity in chronic liver diseases. Introduction Hepatocellular carcinoma HCC is a major health problem worldwide with more than 5 00 000 cases diagnosed annually 1 . There has been an increase in the incidence of HCC over the last 5-8 years however the survival of those who have been diagnosed as HCC has not changed significantly in the last two decades 1 2 . Etiologies of the tumors in our HCC p atients were mainly in alcoholic and non-alcoholic fatty .
