Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Malignant inguinal monophasic synovial sarcoma: report of a case and review of the literature | Xu et al. World Journal of Surgical Oncology 2010 8 102 http content 8 1 102 WORLD JOURNAL OF SURGICAL ONCOLOGY CASE REPORT Open Access Malignant inguinal monophasic synovial sarcoma report of a case and review of the literature Ji Xu1 Jia Wang2 Long Cui1 Xiangru Wu2 Abstract Background A synovial sarcoma SS is an aggressive soft tissue tumor that classically occurs in the extremities near but rarely within large joints in young adults. Variable symptoms and clinical manifestations may be encountered and a definite diagnosis should depend on pathological results. This poses certain difficulties in arriving at a prompt diagnosis and appropriate treatment. Case presentation We report the case of a 68-year-old woman patient who presented an inguinal mass with swelling and pain in the right lower limb. She underwent surgery and later received systematic intravenous chemotherapy. The pathological studies especially the specific chromosomal translocation of a t X 18 confirmed the diagnosis as a synovial sarcoma. To the best of our knowledge this is the first report of a monophasic synovial sarcoma in the inguinal region. Conclusion Besides making the readership aware of the rarity of location and age of this present case this report distinctly highlights the great value of a molecular analysis of an SYT associated genetic alteration in the diagnosis of synovial sarcoma occurring at rare sites especially when immunochemical results are equivocal. Background A synovial sarcoma SS is an aggressive soft tissue tumor which mainly occurs in the para-articular region of extremities with a predilection of lower limb. It usually develops in adolescents and young adults between the age of 15 and 40 years 1-3 . The detection of a reciprocal translocation between chromosomes X and 18 t X 18 has led to the identification of an SS18 gene also known as SYT rearrangement being involved in the formation of a SYT-SSX fusion protein in synovial sarcomas 4-6 . With
