Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on κ α NF-κB binding activity and TNF-α secretion of T cells. | Available online http content 4 3 184 Research article Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on NF-kB binding activity and TNF-a secretion of T cells Dirk Pohlers1 Carsten B Schmidt-Weber2 Angels Franch3 Jurgen Kuhlmann4 Rolf Brauer5 Frank Emmrich6 and Raimund W Kinne1 Experimental Rheumatology Unit Friedrich Schiller University Jena Germany 2Swiss Institute of Asthma and Allergy Research SIAF Davos Switzerland 3Faculty of Pharmacy University of Barcelona Barcelona Spain 4Max Planck Institute of Molecular Physiology Dortmund Germany institute of Pathology Friedrich Schiller University Jena Germany institute of Clinical Immunology and Transfusion Medicine University of Leipzig Leipzig Germany Correspondence Raimund W Kinne MD Experimental Rheumatology Unit Friedrich Schiller University Bachstr 18 D-07740 Jena Germany. Tel 49 3641 657150 fax 49 3641 657152 e-mail Received 23 July 2001 Revisions requested 9 October 2001 Revisions received 5 November 2001 Accepted 8 November 2001 Published 8 January 2002 Arthritis Res 2002 4 184-189 2002 Pohlers et al. licensee BioMed Central Ltd Print ISSN 1465-9905 Online ISSN 1465-9913 Abstract The aim of this study was to analyze the differential effects of three anti-CD4 monoclonal antibodies mAbs with distinct epitope specifities in the treatment of rat adjuvant arthritis AA and on T-cell function and signal transduction. Rat AA was preventively treated by intraperitoneal injection of the anti-CD4 mAbs W3 25 OX35 and RIB5 2 on days -1 0 3 and 6 . 1 day before AA induction on the day of induction day 0 and thereafter . The effects on T-cell reactivity in vivo delayed-type hypersensitivity ex vivo eoneanavalin-A-indueed proliferation and in vitro mixed lymphocyte culture were assessed. The in vitro effects of anti-CD4 preincubation on TCR CD3-induced cytokine production and signal .
