Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Combined antibiotic and free radical trap treatment is effective at combating Staphylococcus-aureus-induced septic arthritis. | Available online http content 4 3 196 Research article Combined antibiotic and free radical trap treatment is effective at combating Staphylococcus-aureus-induced septic arthritis Egidija Sakiniene and L Vincent Collins Department of Rheumatology University of Goteborg Sweden Correspondence Egidija Sakiniene MD PhD Department of Rheumatology University of Goteborg Guldhedsgatan 10A 413 46 Goteborg Sweden. Tel 46 31 3422962 fax 46 31 823925 e-mail Received 30 August 2001 Revisions requested 18 October 2001 Revisions received 21 November 2001 Accepted 29 November 2001 Published 15 January 2002 Arthritis Res 2002 4 196-200 2002 Sakiniene and Collins licensee BioMed Central Ltd Print ISSN 1465-9905 Online ISSN 1465-9913 Abstract Although early antibiotic treatment of patients with septic arthritis eradicates bacteria joint destruction commonly results from the unregulated host inflammatory responses to infection. The spin trap compound phenyl-N-tert-butyl nitrone PBN has been shown to have both anti-inflammatory and antioxidant effects. The aim of this study was to assess the effect of combined systemic administration of PBN and oxacillin on the development of Staphylococcus aureus arthritis. Three days after Naval Medical Research Institute NMRI mice were infected intravenously with S. aureus LS-1 daily treatment was started with cloxacillin alone PBN alone or cloxacillin and PBN. Arthritis weight loss and general condition were evaluated for each mouse and joints were analyzed histopathologically. Systemic administration of PBN in conjunction with cloxacillin ameliorated the course of experimental S. aureus arthritis as evidenced by an increased cure rate. Thus combinatorial antioxidant plus antibiotic anti-inflammatory therapies represent a potentially efficacious approach to the management of septic arthritis. Keywords arthritis murine spin-trap Staphylococcus aureus treatment Introduction Staphylococcus aureus
