Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Cartilage-specific autoimmunity in animal models and clinical aspects in patients – focus on relapsing polychondritis. | Arthritis Research Vol 4 No 5 Hansson and Holmdahl Review Cartilage-specific autoimmunity in animal models and clinical aspects in patients - focus on relapsing polychondritis Ann-Sofie Hansson1 and Rikard Holmdahl2 Department of Clinical Immunology Sahlgrenska University Hospital Gothenburg Sweden 2Section for Medical Inflammation Research BMC Lund University Lund Sweden Corresponding author Ann-Sofie Hansson e-mail Received 23 May 2002 Revisions received 18 June 2002 Accepted 21 June 2002 Published 17 July 2002 Arthritis Res 2002 4 296-301 2002 BioMed Central Ltd Print ISSN 1465-9905 Online ISSN 1465-9913 Abstract Relapsing polychondritis is an autoimmune disease in which an inappropriate immune response destroys cartilage. Cartilage of the ears larynx and nose rather than spine and joint cartilage is affected by a chronic relapsing and erosive inflammation. Several animal models for relapsing polychondritis have been published in which immunization with various cartilage proteins induces a variety of chondritis symptoms that mimic those seen in patients. In this review we describe the collagens matrilin-1 and cartilage oligomeric matrix protein as potential autoantigens able to trigger the tissuespecific immune response seen both in patients and in animal models for relapsing polychondritis and related autoimmune diseases. Keywords collagen matrilin model relapsing polychondritis rheumatoid arthritis Introduction Relapsing polychondritis RP is a rare disorder which primarily affects cartilage in the upper respiratory tract the ears and the nose. Joints are affected as well but as a non-erosive arthritis. Like rheumatoid arthritis RA RP has been associated with the HLA-DR4 molecule in a few studies. In addition patients with RP and RA present symptoms within the same cartilage structures but with large variations in severity. Animal models that mimic the symptoms of the human disorder could be used as a tool to investigate the .
