Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome. | Available online http content 7 1 R30 Research article Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome Joyce Villanueva1 Susan Lee1 Edward H Giannini2 Thomas B Graham2 Murray H Passo2 Alexandra Filipovich1 and Alexei A Grom2 Division of Hematology Oncology Children s Hospital Medical Center Cincinnati Ohio USA 2William S Rowe Division of Rheumatology Children s Hospital Medical Center Cincinnati Ohio USA Corresponding author Alexei A Grom groma0@ Received 13 Jul 2004 Revisions requested 10 Sep 2004 Revisions received 21 Sep 2004 Accepted 27 Sep 2004 Published 10 Nov 2004 Arthritis Res Ther 2005 7 R30-R37 DOI ar1453 2004 Villanueva et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Macrophage activation syndrome MAS has been reported in association with many rheumatic diseases most commonly in systemic juvenile rheumatoid arthritis sJRA . Clinically MAS is similar to hemophagocytic lymphohistiocytosis HLH a genetic disorder with absent or depressed natural killer NK function. We have previously reported that as in HLH patients with MAS have profoundly decreased NK activity suggesting that this abnormality might be relevant to the pathogenesis of the syndrome. Here we examined the extent of NK dysfunction across the spectrum of diseases that comprise juvenile rheumatoid arthritis JRA . Peripheral blood mononuclear cells PBMC were collected from patients with pauciarticular n 4 polyarticular n 16 and systemic n 20 forms of JRA. NK cytolytic activity was measured after co-incubation of PBMC with the NK-sensitive K562 cell line. NK cells CD56 T cell receptor TCR -aP NK T
