Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Chemokine receptors in the rheumatoid synovium: upregulation of CXCR5. | Available online http content 7 2 R217 Research article Chemokine receptors in the rheumatoid synovium upregulation of CXCR5 Caroline Schmutz1 Alison Hulme1 Angela Burman2 Mike Salmon2 Brian Ashton1 3 Christopher Buckley2 and Jim Middleton1 3 Leopold Muller Arthritis Research Centre Robert Jones and Agnes Hunt Orthopaedic Hospital Oswestry UK 2Division of Immunity and Infection Medical Research Council Centre for Immune Regulation University of Birmingham Edgbaston UK institute for Science and Technology in Medicine Medical School Keele University Stoke-on-Trent UK Corresponding author Caroline Schmutz Received 9 Aug 2004 Revisions requested 23 Aug 2004 Revisions received 7 Oct 2004 Accepted 1 2 Nov 2004 Published 16 Dec 2004 Arthritis Res Ther 2005 7 R217-R229 DOI ar1475 2004 Schmutz et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Open Access Abstract In patients with rheumatoid arthritis RA chemokine and chemokine receptor interactions play a central role in the recruitment of leukocytes into inflamed joints. This study was undertaken to characterize the expression of chemokine receptors in the synovial tissue of RA and non-RA patients. RA synovia n 8 were obtained from knee joint replacement operations and control non-RA synovia n 9 were obtained from arthroscopic knee biopsies sampled from patients with recent meniscal or articular cartilage damage or degeneration. The mRNA expression of chemokine receptors and their ligands was determined using gene microarrays and PCR. The protein expression of these genes was demonstrated by single-label and double-label immunohistochemistry. Microarray analysis showed the mRNA for CXCR5 to be more abundant in RA than non-RA .
