Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:The role and clinical implications of G6PI in experimental models of rheumatoid arthritis. | Arthritis Research Therapy Vol 7 No 1 Kamradt and Schubert Review The role and clinical implications of G6PI in experimental models of rheumatoid arthritis Thomas Kamradt1 2 and David Schubert2 1Institut fur Immunologie Klinikum der Friedrich-Schiller Universitat Jena Jena Germany 2Deutsches Rheumaforschungszentrum Berlin Berlin Germany Corresponding author Thomas Kamradt Immunologie@ Published 30 November 2004 Arthritis Res Ther 2005 7 20-28 DOI ar1476 2004 BioMed Central Ltd Abstract The antigens that trigger the pathogenic immune response in rheumatoid arthritis RA remain unknown. Until recently it was assumed that either viral or microbial antigens or joint-specific antigens were the target of arthritogenic T and B lymphocytes in RA. Consequently murine models of arthritis are induced by immunization with either joint-specific antigens such as type II collagen or microbial products such as streptococcal cell wall. In the K BxN T-cell receptor transgenic mouse model arthritis is caused by a systemic autoimmune response to the ubiquitously expressed glycolytic enzyme glucose-6-phosphate isomerase G6PI . The autoreactive transgenic T cells recognize G6PI and provide help for the production of arthritogenic IgG antibodies against G6PI. More recently it was shown that G6PI immunization induces severe symmetrical peripheral polyarthritis in genetically unaltered DBA I mice. In that model CD4 T cells are necessary not only for the induction but also for the effector phase of arthritis. Here we review the pathomechanisms that lead from systemic autoreactivity to arthritis in these models consider the relevance of anti-G6PI immune reactivity for RA and discuss the insights into the pathogenesis of RA and possibly other autoimmune conditions that can be gained from these models. Keywords arthritis CD4 T lymphocytes DBA I mice FCy receptors glucose-6-phosphate-isomerase Introduction The aetiology of rheumatoid arthritis RA which affects .
